Chemistry Nobel Prize 2010 - Periodic Table of Videos

[joeylawn36111]

at least the winners are deserving - unlike the Peace Prize sometimes......

[sterling729]

When they did the reaction, why did they have a reflux apparatus???? they're not heating it up.

[SSJkiller]

@sterling729

It's there just in case the reaction doesn't take place, since Suzuki reactions sometimes need additional energy to get them going. A reflux apparatus is also helpful for keeping the reactants in solution over long periods of time, since any evaporated solvent will immediately condense back into the reactant solution.

At least that's how I see it.

[TerminatoR99]

this is halarious!

hahaha

i love how he uses dog toys XD

[HWGuyEG]

@TerminatoR99

Soo many dog toys, there's like 3 boxes of them.

[G3org3Master]

I WISH I FUCKING UNDERSTOOD.

[Mocni]

I love how all the Professor's examples use dog toys.

[unknownareadaniel]

I need this video subtitled in portuguese!! I couldn't understand some things :(

[lexichronicle2]

Say YES to Nobel prize awards and NO to citation based journal ranking!

I have some of the chloride and noticed it has changed colour a little over the years, from an orangey brown more towards a coca cola brown.

They may have done the anhydrous work that way to demonstrate the idea of using syringes and septums, then pulled the condenser to get it going for the video.

I'm investigating an SPS system for at home use, but using pipettes for the columns.

[Sheynan55]

dam the profesor is vert sheyky

[buzzausa]

As an organic chemist it made me really happy to hear about this year's Nobel proze in chemistry.

Palladium -mediated C-C bond forming reactions are really at the core of what we do.

Other than Stille I think that Sonogashira also deserves a honorable mention.

[MrrrMagoo]

First of all I want to say that I realy like these films from periodicvideos - thanks for great and fun popular chemistry knowledge on YT (from a Chemistry/Biotechnology scholar/student) ! :-)

Allthough the prize in chemistry this year goes to a method that descibes a useful means of carbon-carbon bonding in organic synthesis, my favorite is the prize for the GFP from a jellyfish!

[TSNam]

Concerning the reaction demonstrating use of the palladium catalyst, it seems odd to make that they would take care to make their reaction air/water free by syringing Na-wire dried THF through a septum and then add reagents that were drawn in open air. I was further shocked when they popped the condensor off to add the palladium catalyst.

If their reaction didn't need to be meticulously air/water free, why use the septum at all?

[pipsproductions15]

The professor should win the nobel prize, for putting up these awesome and intresting videos!

[cama9103]

wow

[rlewis1946]

A lay person's question... How do you know you have created a C=-=C bond? You can't see it.... can you? Thank you for all your good work in making these fascinating, five star, videos!! Best wishes and highest regards, Roy Lewis Atlanta, Georgia USA

[sarahkirky]

@rlewis1946 You can't see it with your eyes...but with analytic machines we can "see" exactly what the structure of molecules are!

[MuneoPollen]

@rlewis1946 You can work it out by looking at how the molecule responds to various things - usually people use a combination of infrared absorbance (which looks at how the molecule vibrates when you hit it with infrared), and NMR (which looks at how the electrons shield the atomic nuclei from microwaves, and so at where the electrons are in the structure). These two techniques together let you work out a lot of information about a molecule.

[halfnovice]

Interesting coincidence that Palladium spiked up today to a nine-year high price.

[RSXdaLV]

Is it always sure that there won't be wrong C=C bonds? Couldn't modified benzene ring bond with another benzene ring?

[ftwelve12]

That is the best fucking tie ever

[silentelysium]

We did the Heck reaction on the day they announced the winners. Very ironic :D We didn't used Pd(PPh3)4 though, rather we used palladium on activated carbon which is really messy :S Congrats to the winners though!

[3doog]

Heck's Reaction

Sound nice!

[yusukeshinyama]

Today I saw many Japanese newspapers celebrating the researchers, but none of them were explaining what's the Suzuki coupling, let alone showing one. This video rocks!

[AlmightScoop]

I remember learning the Suzuki coupling in organic chemistry lectures. Thanks for the Nostalgia ;-)

[Cickarn]

Hi there!

I have a question

So, what is the relation between this experiment and Discodermia dissoluta?

[Telamond]

@Cickarn If you go into nobelprize org, you will find under this years chemistry Nobel laureates webpage a link with "popular information" on this .pdf on page 2 you will find an image of (+)discodermolide (the active substance). It is used for the C-C bond formation marked with a red ring.

[mackinnon182]

Could something be added about grignard reaction?

Organic chemistry is well good

[pwn0grapher]

Plane crash my ass! Investigate the other three winners, the death is no accident...

[mr0myster]

I did both the Heck and Suzuki reactions in lab. I was so excited when I heard the Nobel prize was going to them this year :)

[Telamond]

@EleVRs Walter Kohn and John Pople was awarded the Nobel Prize in 1998 for their work in computational chemistry. And if you want real theoretical chemist you would have to look far back to the days when Niels Bohr was awarded the prize.

[rowanofrin1]

The experiment at the end was ridiculously exciting to watch for me. I can't wait until I am at that level. Keep up the great work!

[CrAzYcArNiE08]

YOU ARE GREAT AT WHAT YOU DO PROFESSOR!

[jony3550]

Kool today is my Birthday :D

[Sancho0330]

Purdue!

[Harshfate]

GOOD ON YOU ORGANIC CHEMIST!!!!! cue music " doooooont stop, belieeeeeeevin" what? just me?

[MonMonsieurBleu]

The Nobel prize is also a wonderful politically motivated tool

[AmetuerChemist]

Does he have a dog, or does he just like having dog toys on his desk???

[Ayjayo]

I knew I was thinking of the wrong thing. I tried remembering what chemical Ironman used the the movies for some reason I was thinking of platinum, it was actually palladium!

[Reqrezentin]

Negishi on the phone was hilarious.

[GuppyPal]

We did this stuff in O-chem all the time. My prof used Pd catalyst regularly in his research, so he really wanted us to understand it.

[cocaclasica]

im gonna study chemistry in london, and i would like to consider working with these guys :)

[captwasabi]

At the very least I think that the Prof & the team @ Uof Nott deserves an honorable mention just for their work in brining chemistry to us unrefined masses. Hell, if Obama can get a peace prize simply for not being George Bush you guys should get an award for your dedication to spreading knowledge.

[killernat]

lol at useing dog and cat toys for examples

[TomMarAlem1987]

Produce a series on famous reversible reactions.

[drchaffee]

Regarding the forth worthy person who sadly passed in a plane crash - I was under the impression that the Nobel Committee does not award more than three people.

[Telamond]

@drchaffee I think the prof was saying that since there are so many people that worked on Pd-catalyzed cross-coupling reactions, the Nobel Prize Commitee was waiting for people to die until they could get down to three people....

Stille was his name btw. Just like Suzuki and Negishi with boron respectively zinc, Stille used stannanes as a transmetallation coupling reagent.

[periodicvideos]

@drchaffee that's right... there is a maximum of three people per prize.

[Muscleduck]

Would it be possible to do a Graphene video?

[Arkalius80]

@Muscleduck They just did the other day...

[Ralphgtx280]

@Muscleduck there already is one

[periodicvideos]

@Muscleduck we did one yesterday for periodicvideos and an even longer on our sixtysymbols channel

[skew47]

I get confused just looking at the professor.

[XSHoCKGuNNeRX]

wow the professor shakes a 'heck' of a lot!

[psionicdreams]

oooh! i want that periodic table tie!

i really do, actually...

[Shannariano]

Research about catalysts is a great thing, but in order to do carbon carbon bonds that's not the only way. How a palladium catalyst would be better than (for instance) a Grignard reaction?

[JesusHChrist2000]

@Shannariano

Better? Just different

[Tagger1020]

@Shannariano

Because the Grignard reaction requires a ketone at the spot of reaction as well as creates an alcohol at the reaction site which would then need to be cleaved creating another step, these reactions require none of those and produce pure carbon-carbon bonds in one step

[risbolla]

I wonder what dog the professor has

[GBrooks87]

@risbolla I'm guessing if he had a dog, it would be a labradoodle! :D

[jacoman1234567]

Three incredible additions to (organic) chemistry. I find a bit of an anticlimax, though, after the graphene physics Nobel Price yesterday, but that's just me =)

[simon4u3]

I love how he uses the dog toys for atomic models!

[Dzakovich000]

It will be an honor to fail Dr. Negishi's class. He's brilliant but usually has trouble conveying information.

[ItsScienceBitch]

Poor Sonogashira, he must be pretty pissed off. Stille R.I.P :(

[mr0myster]

@ItsScienceBitch Lol'd at the Sonogashira comment. I don't know why, but I always hated the Sonogashira coupling.

[ItsScienceBitch]

@mr0myster Don't hate on Sonogashira now, especially in his current fragile, warped, Swedish hating state. They should at least have mentioned him in the video. Poor guy probably in a dark place at the moment.

[ChiefDen4]

Wow, chemistry never ceases to amaze me.

[philsaspiezone]

Looks as though there must be an organometallic intermediate which might generate a carbanion.

[guitarfreaky1996]

good eveing doc.. i was wondering after this nobel chapter, if you could talk about the einstein test.. i had passed it when i was 12..... and i decided to do it again last month and so i did... i wanted to know the brain process through out the test.. and why 2% cant pass it.. i mean... it's very easy i was wondering if there was any kind of illusion.. please answer

[DeoMachina]

@guitarfreaky1996 I think these internet tests can be misleading, don't take them as anything more than a bit of fun.

[guitarfreaky1996]

@DeoMachina u suggest me doing a paper one?

[DeoMachina]

@guitarfreaky1996 It would probably be more accurate but I don't see much point in that either.

[homousios]

This coupling, I like to see again and again. Thanks!

[snowborednow]

Suzuki is at Hokkaido University! Go Hokudai!

[James23TT]

awesome tie :)

[billy9038]

Ei-Ichi Negishi is a professor at Purdue!

[KilgothMirna]

Looks a little like Grignard-reactions. Probably not surprising.

[KilgothMirna]

@KilgothMirna oh btw.: Why do organic chemists never use Schlenk equipment? It makes working under inert gas atmospheres so much easier compared to those unhandy balloons o.o

[mr0myster]

@KilgothMirna I don't know, I kinda like the balloons more. They're not really that unhandy. Also, Schlenk equipment's pretty pricey and balloons are... well, let's say more easily available :)

[LordMigit]

i love how the prof has a load of completly random items around his desk which get used in demonstraiting molecules.

[TomMarAlem1987]

Is the reaction reversible?

[Telamond]

@TomMarAlem1987 No it is not. 

[Zeldakitteh]

I hear Swedish. =D

[gulllars]

@Zeldakitteh yes, the guys says in swedish that the prize goes to palladium catalyzed carbon-carbon bonding reactions, you can clearly hear palladium and catalyzed ("Palladium-katalyserade" is what he says)

[ShortGuy1792]

I am amused by the professors use of dog toys in his explanation. :D

[Telamond]

It was really due time that Heck, Suzuki and Negishi won. I'm a Pd-chemist as well and I'm very pleased and excited for this years Nobel laureates! :)

[PartVIII]

i am currently a Gen. Chem. undergrad at Purdue.

small world

[oobermate]

I love your videos =) keep up the great work. Those three men won a very well deserved Nobel Prize indeed.

[georpthey]

@oobermate I concur *pushes up glasses, straightens tie* good vids though :)

[odyssoulis]

i love chemistry !!!!! :))

[doggydidadoodoo]

apparently my patient refreshing was too patient! only 107th -great video, though :)

[jitakyoeiJL]

great video thank you!

[TeoTheAwesome]

@oggybodoggy Noice.