Joe DeRisi: Hunting the next killer virus

[crudhousefull]

Wow...a real life virus guard. This time medicine for humans follows procedures for the computer. Incredible on so many levels

[RobbiMedofficxeer]

thank you for the video. it's great! if you are looking for the full one visit

watch W5 last W5 movies . coooooom (remo ve W5's)

[dinogrower]

Best TED talk ever is what I am feeling now!

[MortalAndKnowingIt]

yes

[ahypnos]

Sheer genius.

[12235117657598502586]

WOW!!!! .....Why aren't we all funding this?

Finger printing every virus & keeping up with the new / mutated viruses that rapidly develop - Awesome!

[Ormaaj]

To quote Peter Griffin: "Why aren't we funding this?"

[moonhitler]

Nice...

[timeoutformike]

Lmfao i love that ep!

[BusinessButterfly]

Ormaaj

I got a better one meet new "CSI Virubiology Agent" this guy is amazing :)

[guitaristapprent]

i think you should use nanotechnology for this

[nytonks]

Can anyone explain how identifying that patient's virus led to curing it?

[GodlyPie]

When the virus is identified, doctors can then use that to find a list of medicines that help the body fight said virus, or medicines to treat the symptoms caused by it.

[nytonks]

It just seemed like they found out it was a rare virus no one knew could cause those symptoms, so it seemed unlikely there would be specific treatments already in place for it...

[LiquidFriction]

Well, if you watched it said patient outcome was cured. Most the time if we know what we're dealing with we can find the cure faster. This is offering to identify viruses and even new viruses and their origins of relation to other viruses to find a common cure. As well as you can see here, it's helping in other ways by showing how prostate cancer very well could be caused by a virus itself.

[unmarkedX]

What is the specific cure of parainfluenza?

It says recovered not cured

[KingRasDasta]

Viruses most man made. Scientists tamper with to many things and nobody knows what there doing. all of a sudden we all getting sick. and nobody knows what happened. they just drop the ball. but im sure they will have a vaccine for you to buy.

[Blackthorn2323]

What about variola polio antibiotics and so on?

fuck off

[AwsomestKill]

kingrasdasta go back to school.

[ke422azn]

This is Amazing!! - something a chemical engineer like me certainly appreciates.

[ladyrose01z]

Wow! I want to hear more. I like this stuff, Bacteriology, Virsus and Parasites.

[nachoboy4]

good job. it will save money and lives!

[xXAzocarXx]

wow!!! I could get A+ in report in science If i will remember all his lines!! xD

[zombievampirealiens]

He sounds like daffy duck XD.

[mickstakes]

I thought intelligent people only watched these vieos guess I was wrong

[Cerberus221]

Sufferin suckatas...xD

[ke422azn]

He also has a doctorate degree and you still live with your mom. Who wins?

[usedforbattle]

I really would love to build one of those machines & add to the genbank ^_^

[semiliteratedgod]

why so chip?

[spadesghost]

that sometimes seems like the truth

[ke422azn]

watch Hollywood video much? Try graduating from college before you talk please.

[ssnatcherss]

Bitch please.... Everyone knows evolution is a lie. There's no such thing as virus mutations...

*cough hhaaachhhhhh cough*

[darinraney]

lol

[eldeberry]

fag i am offended

[ke422azn]

Yeah, everyone except all universities, colleges, high schools and every biology text book out there.

[ssnatcherss]

I guess that simple joke was over your head...

[lilcryingangel]

you put virus on a chip and send it across the internet via your pc thats evolution

[sy1234]

Wow..

[chick5581]

Hilarious! well done!! normally videos bore me.. well some of them but this one kept me in tune through out the whole thing.. realy talent you have.

[wii2050]

Luckily robots, the futures workforce, don't have cancer, but they might suffer from viruses.

[Mrmoc7]

Hahahah, yea.

[ONENEVERFOLLOWS]

Awsome!! Great Work you are more than on to somthing , The world needs thinkers like you.

[j0hnwi11iams]

Now we see medicine reaching the computer age.

[iurak6868]

great talk!, very smart guy, it strikes me that no one complaints when he uses the word "evolution".

i've seen so many stupid creationist videos that everytime i hear the word evolution i twicht....

[rackslap]

does this guy remind anyone else of Matt Frewer? (honey i shrunk the kids) with a bit more of a lisp.

[Rikotistic]

kewl. Not the next virus but the presentation.

[puellanivis]

Oh My Universe! (I'm trying to stop swearing to any particular god, since I don't believe in any of them.)

This is perhaps the most interesting and amazing thing I have ever seen. We could totally make these chips for genetic disorders, and produce the same thing for genetic predispositions. Oh wait... we're trying to avoid Gattaca... Still, I would like to know.

[kwolity]

"Oh My Universe!"

Best exclamatory phrase ever!

[joemarklawson]

"totally make these chips for genetic disorders, and produce the same thing for genetic predispositions."

It's been done already. Look up 454 Life Sciences. Total genome sequencing in less than a day. That's actually far more advanced than what Joe is talking about, which is 15 year old microarray technology. Microarrays cost about $500/chip. 454 probably more like $10,000.

The difference is: 454 actually sequences the unknown, microarrays rely on sequence specific hybridization.

[puellanivis]

I don't care about unknown sequences in this case. If I wanted the whole map, I'd go to deCODEme, which does full genome for $1,000. I'm rather thinking of fairly inexpensive and relatively quick tests, which can test for "all known" genetic disorders.

Is it limited in scope? Yes. It certainly is. But the idea is pass up scope for cost. Like you said, this microrray is just $500/chip.

[joemarklawson]

deCODE doesn't do sequencing. What they do is SNP genotyping. Big difference.

You won't get a "full genome" for $1000. You can test a panel of SNPs, but you don't get sequence context, and you can't discover anything new with that.

If the NEXT KILLER VIRUS shows up in your doctor's office, the test may show that it is related to HSV-1 and also to coxsackievirus, but it won't tell you that this sequence represents a new virus.

That's where his test it limited.

[joemarklawson]

And if we port this to an FDA approved test (IVD), remember that the cost will go up. A good rule of thumb is 10X. So a

$500 dollar test will cost $5000 in a clinical environment.

I saw a press release from 4 days ago that a spin-off of deCODE, Nimblegen, are partnering with 454 to make a chip-to-sequence pathway for the human exome.

Molecular biology, bringing you the future ahead of schedule.

[GetMeThere1]

Very very cool. Excellent stuff. Probably though, this talk should have been dumbed-down a bit (or SLOWED down), for the average TED audience.

[iurak6868]

LOL

[Mastikator]

Very cool machine. It's almost something you'd see in a sci-fi series.

[BGSoccerMagic]

I love it how, when he started talking about the posible retroviral link to some of the prostate cancer cases, the audiance got dead quiet.

[sockpuppetsfromhell]

Very cool. This is a truly excellent talk.

[kawuabonga]

hi!

[sockpuppetsfromhell]

:-)  Hello.

[Mackaframmalamma]

I love smart people

[italianchappy]

Great vid. Great for our health and even for our welfare. I mean, these are the guys who will carry through our economic troubles as well. You get economic advances when there are scientific and technological discoveries and applications. In the roaring twenties cars, in the nineties internet. Now it's time for health advances. A huge aging population in the world is waiting for it.

[Promatheos]

This guy is talking over the layman's head, but from what I got out of it, this should help with diagnosis.

[asocietyred]

future of medicine

[BGSoccerMagic]

"future of medicine"

no, its the future of pathogen diagnostic, if not more

[jack4440]

So the hospital was just throwing antibiotics at the patient? Aren't they just asking for the bacteria the develop resistance?

[Br0k3nS41nt]

What are they supposed to do? Let her die on the small chance the virus may become resistant? That is what you are supposed to do and what they do do, put you on a shit load of antibiotics when they don't know what is killing you.

[Br0k3nS41nt]

Bacteria rather... My bad.

[BGSoccerMagic]

they didnt even know if it was a virus or not? they were just aiming blindly. maybe hospitals and the whole health care system should work more closely with the researches than they are now - it benefits everyone.

[puellanivis]

I think the best thing about this, is that it shouldn't be a last step. It's relatively cheap, and could be totally run in parallel. They could even do this with the understanding with local healthcare under the conditions that "this is not definitive, nor FDA approved for testing.  Our test might be wrong... BUT, we're checking for a larger range of viruses."

At least, bleh, go for this before $100k of tests has been spent...

[c6gunner]

Wow.  That's pretty amazing.

[SaintCeltic]

1st

[Radjehuty]

This is awesome. Incredible potential here to diagnose more accurately and MUCH less expensively.

[Blackliam]

what the fuck is wrong with you

[conoba]

There must be a factory somewhere, producing retards that make these "OMG I IS FOIST!" posts.

One day someone will find that factory and nuke it from orbit, for mankinds sake. I hope.

[flapjacks3276]

i came from the second factory, haha

[loturos]

jealous.

[buckfush12]

Do you really have to care? Is there some factory that makes crusty assholes like you with sand in your vagina?

[DerFlo4711]

lol

[loturos]

whats wrong with me? whats wrong with you, and your emotional response?

[italianchappy]

I see you're from Luxembourg, it must be a world wide spred gene responsible for this compulsive need to sign as first and second. Dunno how old are those having this illness, but they come from all over the world. Maybe the same guys accelerating their car when someone surpass them ?

[loturos]

why is it wrong to say i was first? you people pretend not to care, but your responses show otherwise. is there something extremely offensive or "politically incorrect" by saying I was first?

i mean, lets assume that its childish, its still equally childish to get offended by it in any way. just ignore it.

[italianchappy]

it's not a serious problem, it could be debatable whether it is wrong, in any case is nothing important. The fact is that everyone who doesn't feel the need of doing it, remains amazed seeing this pointless competion. I gues it's psychological insightful. Those feeling this urgence could benefint from thinking of it and see if somehow the same impulse is conditioning in a certain way their ordinary life. However I never took offense from it. It's an amusing personality trait, imho.