Yay, Science!

[mymojorisin]

LOL A lab coat and props does not make a scientist. What a moron.

[UNFFwildcard]

@mymojorisin

Troll harder next time.

[myjizzureye]

Come on own up, you have been feverishly working on a cure to male pattern baldness that is as so far.....not really bearing much fruit.

[pineconesaresmallnow]

Untreated sample of SOD proof that aliens exist???

[migkillertwo]

yeah mr. white! YEAH SCIENCE!

[truvelocity]

My oldest and one of only two brothers died of brain cancer and my Uncle has the same exact brain cancer. I will say, life is a bitch, but as long as we have biochemical engineers and people willing to understand gene expression, we can get closer to finding out what we can do to suppress that expression. I'm not biochemist, but I get enough of the gist to know when someone is making sense or not

[MorphicStates]

This is so far over my head... O.o

[helical4]

Hey, do you know if those who are homozygous for Sickle-cell Haemoglobin and that also express fetal Haemoglobin are immune to Malaria?

[GoforBrokeVideos]

I guess this would mean that other drugs like calcium channel blockersnwould have a potential to treat sickle cell disease. Anyway, very interesting stuff. The only problem is that the drugs which are currently used have short half lives. As I recall isosorbide mononitrate has the longest and its only 2 or 4 hours.

[GoforBrokeVideos]

so if CO2 is excreted faster from the microcirculation the pH would be higher in this blood, and if the pH rises, the oxygen affinity of hemoglobin would increase, therefore there would be less desaturated Hb, so it would be less likely to sickle.

[GoforBrokeVideos]

Interesting video. As I recall possesing a copy of the thalassemia gene (alpha thalassemia) also reduces the severity of the disease, besides fetal hemoglobin. Also how does NO work for sickle cell anemia? My hypothesis would be that drugs which increase NO in the body like sodium nitroprusside and nitroglycerine cause vasodilation, and therefore increase blood flow to arteries so that waste products of cellular metabolism like carbon dioxide are excreted faster from arterioles (cont...)

[hugesinker]

Atoms are only a theory, not a fact.

[BlowDevilUp]

What about using microarray technology to determine the "protein expression patterns"?

[UNFFwildcard]

I could, but then I would have to re-develop the methodology from scratch. Simple native PAGE serves me well.

[Gameboygenius]

I'm going to ask you a "difficult", yet crucial question. Does Dr. Uzoegwu also propagate the idea that HIV doesn't cause AIDS? (Or anything in that direction...)

[UNFFwildcard]

No, he does not teach that. And to answer the other looming question that I know you're thinking, he teaches that while condoms are safer than unprotected, they are not sure-fire, and that abstinence is the only way of protecting yourself from the virus that is 100%.

[Gameboygenius]

@UNFFwildcard Thank you. I appreciate the honesty. :)

[NashvilleKildCountry]

@UNFFwildcard

I completely agree on the abstinence thing, and I'm not really religious. I just think it's the only fail-safe preventative measure against STI's and getting someone pregnant.  I can kiss my college degree and life ambitions goodbye if I get some girl pregnant. 20+ years is simply not worth the ~20 minutes of physical satisfaction, no matter how supposedly narrow the risks are.

[truvelocity]

I know its not precise nor detailed as molecules and how they react with enzymes. But, I do take systemic enzymes which are available in raw plant foods. Hope to enjoy more on the molecule you are studying, though.

[manutdfan4321]

so are those with a asymptomatic sickle cell anemia at adulthood ,still producing sickle cells but its because the fetal hemoglobins are somehow overriding the effects? Or do they just not express it phenotypically and at the same time they are expressing fetal hemoglobins?

[manutdfan4321]

@manutdfan4321 if the latter is true why don't they express it phenotypically? Or maybe its neither...

[UNFFwildcard]

Unfortunately, I am not familiar with the regulation of adult and fetal erythropoiesis, so I cannot give you a definitive answer. However, I would assume that there would still be sickle cell formation, though their detrimental effects would be migitated by the functioning fetal variety circulating about. Cickle hemoglobin have a very short lifespan, and are eliminated quickly by the lymphatic system, so fetal cells would greatly outnumber the dysfunctional adult cell.

[UNFFwildcard]

Furthermore, while cickling happens in low oxygen environments such as capillaries, the working hemoglobin will inhibit this by continuously delivering oxygen to those environments. You can also reason that if sickle heterozygotes are mostly asymptomatic as well - and they still have some cickle cells - then adult fetal Hb expression should theoretically be able to produce the same observed phenotypic outcome even if some adult sickle Hb is present.

[BlowDevilUp]

@UNFFwildcard Is there some significance attached to the two ways you're spelling 'sickle'?

[UNFFwildcard]

Indeed,there is some significance - namely, that I can't spell!

[thunderbolt94]

I will admit, wildcard, a lot of this went over my head. Then again, I'm a writer, not a scientist! :P Interesting stuff nonetheless.

I'm still willing to contribute to the charity. :)

[TheLiberalSoup]

good video, i never thought NO was such a meaningful word

[AtheismandSkepticism]

It's ok, not everyone can be a physicist...

[startreking2007]

So that is the face to the name, cool