Folding of villin protein simulated on GPUs

[pjsteinsongs]

I agree, that, in the immediate environment of a billiard ball, one can explain the trajectory of one ball, struck with a certain force at a certain angle, by another ball; I wanted to convey that there is a microcosm of these minute, physiochemical events, recurring trillions of times, in trillions of molecular cascades, among trillions of elemental particles, that somehow interconnect, and have a final common pathway that leads to a single, purposeful event, such as my typing this word to you.

[pjsteinsongs]

Is this not anthropomorphism? The proteins are "trying" to assemble? or know what feels "right"; or a "state that's better"? The blue phenylalanine is "perfectly happy to stay in a state like this"? My reasoning: all these biochemical activities, movements, interactions, are by chance, are random, selected over hundreds of millions of years. Random connections have survived through natural selection, embedded in the genome.These are chance collisions, without consciousness, without goals...pete

[JesseVictors]

@pjsteinsongs These activities/movements are not random. They occur as a direct result of the interplay of all the molecular forces acting upon the elements in the protein, kind of like billiard balls don't disperse randomly when you strike them at the start of a game. The proteins need to assemble before they can do anything functional. Optimally, the proteins would exist in a "comfortable" state, where the forces are stable/limited. Hydrophobic regions want to avoid water for example.

[22biochemist]

How is a chaperone protein involved in protein folding? Does it create the hydrogen, ionic, sulfhydryl, etc. bonds in the tertiary structure? Or does it form the other types of structures?

[Puddy88]

@22biochemist They provide a hydrophilic environment for the protein and functions more in preventing bad folding that might occur in the cytoplasm. At least that's what the chaperonin complex in E.coli does. I'm not sure if every protein requires this. Probably not.

[jch607123]

wow

[myfood123]

if you pause exactly at 1:10 or some where around there

the blue thing formed a penis rofl

[inventorOz84]

lovely.

[Lahmy88]

cool