HELP with Opiate Tolerance

[racrx32]

25 40 mg methadone wafer's? This guy is full of shit!

[Way2Spirited]

"DRUG HOLIDAYS" do NOT work! They create unnecessary SUFFERING and any sensitivity to opiates that is created, is undone and goes back to 'normal' within 2-3 days of returning to your dose from the so called "drug holiday"... it should be called drug HELL or drug TORTURE. Putting someone through the hellish torture of withdrawls when they are already in severe chronic pain is just absolutely and unequivocally CRUEL and that is why NO ONE with personal experience with this would ever advocate it

[superotter77]

Unbelievable. Opiophobia, which this doctor is clearly expressing, is a crime against humanity. Drug "holidays" are torture and completely unnecessar, as are ceiling doses of pain meds, since everyone has different tolerances and pain levels. To all you able-bodied opioid fear-mongers, try having your testicles in a vice grip that's constantly being tightened, and then not allowed pain relief for it. Chronic pain sufferers need WHATEVER DOSES IT TAKES to manage their pain, period!!

[superotter77]

@superotter77 (I am specifically only referring to opioids as they have no ceiling dose, meaning the point at which a drug becomes toxic).

[superotter77]

Unbelievable. Opiophobia, which this doctor is clearly expressing, is a crime against humanity. Drug "holidays" are torture and completely unnecessar, as are ceiling doses of pain meds, since everyone has different tolerances and pain levels. To all you able-bodied opioid fear-mongers, try having your testicles in a vice grip that's constantly being tightened, and then not allowed pain relief for it. Chronic pain sufferers need WHATEVER DOSES IT TAKES to manage their pain, period!!

[CNSagent]

He's a perfect way to limit the dose needed for effective opioid analgesic releif: prescribe synthetic cannabinoids (or natural is state does not prohibit) along with opioids.

Cannabinoids produce cross-tolerancce between opioids, but ironically, only a small dose of an opioid is needed when taken in combination with cannabis or a cannabinoid.

Combining cannabinoids with opioids would not only lower the amount of opioids needed, but it would offer patients a better chance at pain releif.

[MisterClean121]

I kinda agree with the doctor in this video, a persons tolerance should never exceed anything stronger than fentanyl, sometimes a person should have a period of sobriety so that tolerance levels are not raised. Because once your tolerance goes up it difficult for you to feel the drug even at high dose.

[brooklynlulu]

Used the whole supply in the hospital on this one patient? Wouldn't she have died after administering such an amount? I live in constant pain do to RA and I have never heard of such an amount in one person. they had me on Fent patch and I didn't say on it, so dangerous. But I suppose all meds have their danger level.

[drewfuss2121]

as an MS patient who has been hospitalized with viral meningitis, numerous spinal-taps, and with several staph-infections requiring cellulitis surgery, I've noticed that before surgeries the dr's like to give fentanyl. Had zero effect on my pain. Don't know why. But I DO know that fetanyl is nothing to mess with. It'll kill ya! Just hope other patients like myself have a better quality of life. Thats all I'm sayin...

[JonesGOP1]

I would LOVE toknow the doc who was giving her 1000mg per day, he's my hero. when I used to go to a methadone clinic I got up to 230mg daily and before Thanksgiving '05 I got a week take home doses and took 4 of them right off the bat That was 920mg at once and I was HAMMERED for about 2 days as I had taken a handful of xanax with this, so it is definately possible to take that much Methadone and live, the xanax just makes it more fun, but of course I don't recommend it to pansies ;-)

[jimsutube123]

ya cuz its soo cool to be perscribed 1 gram a day. loser

[JonesGOP1]

OH sorry Jimspolesmoke I know I forgot to give credit where it is due and your Mom really helped me enjoy my high ass I pounded her poop shute all evening then Robot Andrew Sullivan came along and gave her the AIDS. LOL tell the bitch I said HIGH! hahaha

[hartbeat00000]

Hi. In Canada alone we pop 466,000 prescription painkillers daily more than any other country per capita other than USA and Belgium. Its the drugs the street kids use now more than any other drugs. And seniors, who have a lot of pain get hooked. hartbeatthehippie

[surgeyX]

1 gram of methadone per day? I call bullshit on that.

[KilonBerlin]

@surgeyX

why not? I get 140mg officialy and I took one day 500mg without any dangerous effects (don't do this @ home kids...),

its extreme of course but I think thats why he is talking about it, the hardest case he can remember..

[surgeyX]

because it stops being affective at around 300 mg

[JonesGOP1]

Whoever told you it stops being effective around 300 is a LIAR there is NO ceiling effect on Methadone

[surgeyX]

That's incorrect -- you only have so many opiate receptors throughout your body, if they are ALL occupied then any more drug taken has nowhere to go. This differs from drug to drug and from person to person, but yes, methadone DOES have a cieling.

[jimsutube123]

no full opiate aganost has any cieling with increased dose is increased side effect, notably contipation and sedation, unlike buprenorphine and other partial opiate agonist which do have a ceiling effect. please do me a favor a research it so and when you see your wrong you wont have to bother responding and looking stupid.

[surgeyX]

IF every opiate receptor in your body is full, whether it's an agonist or antagonist, where are they going to go? Answer that.

[jimsutube123]

over time our brains when indroduced to increasing amount of opiates create new receptors for the opiods to attach. which is one of the reasons people experience PAWS or post acute withrawl syndrome after an opiate detox. at least thats what the medical journals i have to read say

[surgeyX]

Thats how methadone works -- you fool. That's why they give people high doses so they can fill up every receptor available, so if one were to use heroin, the heroin would have no receptors to bind to, because the methadone is taking them all up.

[mynthon11]

@surgeyX

Methadone does NOT HAVE CIELING LIMIT, BUPRENORPHINE HAS, and if u are on methadone its bullshit that smack dont work taking it while on juice...Its that, coz u would have to take really much heroin to get high and there is obvious od risk there...And what do u mean they give people high doses of methadone so it fill up every reseptor?It doesnt bind in every opioid reseptor ...

[surgeyX]

@mynthon11

I think you either need to learn English or make use of a spell checker.

[mynthon11]

@surgeyX

Whats your problem? Why dont u try to write some finnish language here and then talk again...and i think youre an fucking retard if u dont understand what i said....ohh wait! u assume everyone here is american, sorry its not like that...What other languages u can speak? It doesnt make u a better person if u play guitar here in web and insulting people here is just pathetic...AND u dont know A SHIT ABOUT OPIOIDS! AND BTW ITS Opioid receptor NOT OPIATE... but u cant tell the diffrence so

[mynthon11]

@surgeyX

SO FUCK OFF!

[mynthon11]

@surgeyX

BTW...U ROCK...U ARE AWESOME QUITAR PLAYER...WHY DONT U JOIN A BAND!!!!! ??? PEACE!

[Armin543]

The problem with methadone is that it blocks other opiates making the Fentanyl virtually useless. Shouldn't an MD know this?

[KClaisse2]

Methadone doesn't block the opiate receptors, your thinking of suboxone or similar drugs.

[falsemesiah420]

this doctor seems very legit , patient concernced, and knowlegable if only i had the money to go to harvard!!!! i hate opiates i haate themmm! fuck hydrocodone fuck hydrocodone fuck oxy codone fuckk ittt oxymorphone toooo fuck that fuckin breakfast of pills =[

[laetrille]

you suck

[NCredneck223]

you have no idea what it's like to cry you're self to sleep u have no idea what its like not being able to get up or role over so screw u

[lishagarcia103]

I miss you Dr Brose

[chrissys31]

I find this to be a very educational video for myself being a methadone patient for addiction to opiate pills and I am going through this problem now but not as extreme but i am on 114mgs and have been on methadone for 4 yrs almost and this is the highest I have been and I really feel I need more but thats what I am doing is creating a ceiling because I know the higher I go I will just get a tolerence to it after awhile. God I hate opiates lol!