The most popular and well recognized ensemble is the Marching Band known as The Magnificent Marching Machine comprised of 150 students.The Magnificent Marching Machine has dazzled and excited audiences during performances at MSU Football Games, National Football League Games, Presidential Inaugurations, World Series, National Playoff Games, and in regional and local television appearances. This ensemble has performed throughout the United States and in Bermuda. The ensemble has also made a cameo appearance in the movie "Head of State" featuring actor-comedian Chris Rock and appeared on Tom Joyner's television show.

MSU band students have performed in intercollegiate bands including the Olympic Band, the All American College Band, The Presidents Inaugural Band, Kappa Kappa Psi/Tau Beta Sigma, HBCU-NBDC, and CBDNA Intercollegiate Bands.